Formulation and Evaluation of Nanoformulation Containing Phytoconstituent of Cardiospermum halicacabum Extract

Authors

  • Suraj Lokhande SVP College of Pharmacy, Hatta Tq. Basmat Dist. Hingoli, Maharashtra - 431705, INDIA.
  • Gunesh Dhembre SVP College of Pharmacy, Hatta Tq. Basmat Dist. Hingoli, Maharashtra - 431705, INDIA. https://orcid.org/0009-0009-2408-7466
  • U. T. Jadhao SVP College of Pharmacy, Hatta Tq. Basmat Dist. Hingoli, Maharashtra - 431705, INDIA.
  • S. T. Thoke SVP College of Pharmacy, Hatta Tq. Basmat Dist. Hingoli, Maharashtra - 431705, INDIA.
  • D. A. Rathod SVP College of Pharmacy, Hatta Tq. Basmat Dist. Hingoli, Maharashtra - 431705, INDIA.
  • V. R. Kauthekar SVP College of Pharmacy, Hatta Tq. Basmat Dist. Hingoli, Maharashtra - 431705, INDIA.

DOI:

https://doi.org/10.55544/jrasb.4.4.3

Keywords:

Lantana camara, Silver Nanoparticles, Nanogel, Topical Delivery, Antibacterial Activity, Antioxidant, Phytoconstituents, Green Synthesis, Drug Release

Abstract

he study aimed to formulate and evaluate polymeric nanoparticles containing phytoconstituents of Cardiospermum halicacabum L. Methods: Ethanolic extract of Cardiospermum halicacabum L. was incorporated into polymeric nanoparticles using the solvent evaporation technique. Poly (lactic-co-glycolic acid) (PLGA) was used as the biodegradable polymer, and polyvinyl alcohol (PVA) served as a stabilizer. Five different formulations (F1–F5) were prepared by varying polymer and stabilizer concentrations. Evaluation parameters included particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, in vitro drug release, and antioxidant activity using the DPPH assay. The stability of the optimized batch (F3) was assessed under accelerated storage conditions. Results: Formulation F3 was optimized, showing the smallest particle size (165 ± 4 nm), low PDI (0.280), and high zeta potential (-28.3 mV), indicating good physical stability. It also showed superior entrapment efficiency (75.6%) and maximum drug release (85.2% at 24 h). Antioxidant studies confirmed free radical scavenging potential of the extract. Stability studies revealed minimal changes in physicochemical parameters over time. Conclusion: The nanoformulation of Cardiospermum halicacabum L. significantly enhances its stability and drug delivery potential. The developed system holds promise for further in vivo studies and future use in the effective management of diabetes.

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Published

2025-08-11

How to Cite

Lokhande, S., Dhembre, G., Jadhao, U. T., Thoke, S. T., Rathod, D. A., & Kauthekar, V. R. (2025). Formulation and Evaluation of Nanoformulation Containing Phytoconstituent of Cardiospermum halicacabum Extract. Journal for Research in Applied Sciences and Biotechnology, 4(4), 19–28. https://doi.org/10.55544/jrasb.4.4.3

Issue

Vol. 4 No. 4 (2025): August Issue

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Articles

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Copyright (c) 2025 Suraj Lokhande, Gunesh Dhembre, U. T. Jadhao, S. T. Thoke, D. A. Rathod, V. R. Kauthekar

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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