Hepatoprotective Effects of Camellia Sinensis Against Tartrazine-Induced Liver Toxicity in Albino Rats
DOI:
https://doi.org/10.55544/jrasb.5.1.22Keywords:
Tartrazine, Hepatotoxicity, Camellia sinensis, TartrazineLiver enzymes, Antioxidant, Oxidative stressAbstract
This study was designed to evaluate the hepatotoxic effects of tartrazine and to examine the protective potential of Camellia sinensis (green tea) in albino rats. Exposure to tartrazine led to noticeable alterations in liver function markers, as reflected by elevated levels of ALT, AST and ALP, which indicate liver damage. Histopathological observations further supported these findings, showing degeneration of hepatocytes, necrosis, and inflammatory cell infiltration in liver tissues. These changes are mainly linked to oxidative stress caused by excessive generation of reactive oxygen species.
On the other hand, administration of Camellia sinensis showed a clear protective effect. The treated group exhibited improvement in biochemical parameters along with restoration of normal liver architecture. This protective action is largely attributed to the antioxidant properties of green tea polyphenols, especially catechins, which help in reducing oxidative stress and maintaining cellular integrity.
Overall, the findings of the study suggest that although tartrazine may induce toxic effects on the liver, natural antioxidants such as green tea can play an important role in reducing such damage and may have therapeutic relevance in managing chemically induced hepatotoxicity.
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